Canine Cyclic Neutroenia( Gray Collie Syndrome)
Go to the HealthGene Site to learn more.
DESCRIPTION Canine Cyclic Neutropenia is a stem cell disorder that occurs
in collies. Puppies are usually smaller and weaker than their litter mates
and by 8 to 12 weeks of age they develop clinical signs such as fever,
diarrhea, joint pain, or other signs associated with eye, respiratory, or skin
infections. The disorder is caused by an abnormality of the stem cells in the
bone marrow, from which all blood cells are developed. The result is a
cyclic fluctuation in blood cell numbers. Every 10 to 12 days the number of
neutrophils drops dramatically, and then rebounds.
There is an increased susceptibility to infection corresponding to the dip in
neutrophil numbers. Affected dogs are subject to severe recurring bacterial
infections, primarily of the respiratory or gastrointestinal tract. These dogs
are also prone to bleeding episodes due to the drop in blood cells numbers.
This is a serious genetic disorder. Even with the best of care, affected dogs
rarely live beyond 2 or 3 years of age. Most die within the first few weeks.
The disease occurs in all gray (not merle) collies. Affected puppies have a
silver gray hair coat that ranges in color from very light, to darkish pewter
gray, sometimes with a slight yellowing due to a mixture of light beige and
light gray hair. No matter what color variation or type, all Collies have black
noses EXCEPT those with gray collie syndrome. If the nose continues to
come in gray, then that is pathognomonic (absolutely diagnostic) for "gray
collie syndrome". Sable "gray collie syndrome" dogs have brown or pale
sable noses, but never black noses as they should have.
DNA TEST
HealthGene Laboratory is the first DNA diagnostic laboratory that has
developed and offered a DNA-based test for Canine Cyclic Neutropenia.
HealthGene's test provides a reliable identification of dogs that carry mutant
gene(s). This test allows a breeder to control the mutant gene frequency in
the Collie breed thus preventing the production of puppies affected with
Canine Cyclic Neutropenia. This DNA test accurately and specifically
identifies normal, carriers (heterozygous) and affected dogs. this test has
been developed for the breeder so we can avoid this disorder
Go to the HealthGene Site to learn more.
DESCRIPTION Canine Cyclic Neutropenia is a stem cell disorder that occurs
in collies. Puppies are usually smaller and weaker than their litter mates
and by 8 to 12 weeks of age they develop clinical signs such as fever,
diarrhea, joint pain, or other signs associated with eye, respiratory, or skin
infections. The disorder is caused by an abnormality of the stem cells in the
bone marrow, from which all blood cells are developed. The result is a
cyclic fluctuation in blood cell numbers. Every 10 to 12 days the number of
neutrophils drops dramatically, and then rebounds.
There is an increased susceptibility to infection corresponding to the dip in
neutrophil numbers. Affected dogs are subject to severe recurring bacterial
infections, primarily of the respiratory or gastrointestinal tract. These dogs
are also prone to bleeding episodes due to the drop in blood cells numbers.
This is a serious genetic disorder. Even with the best of care, affected dogs
rarely live beyond 2 or 3 years of age. Most die within the first few weeks.
The disease occurs in all gray (not merle) collies. Affected puppies have a
silver gray hair coat that ranges in color from very light, to darkish pewter
gray, sometimes with a slight yellowing due to a mixture of light beige and
light gray hair. No matter what color variation or type, all Collies have black
noses EXCEPT those with gray collie syndrome. If the nose continues to
come in gray, then that is pathognomonic (absolutely diagnostic) for "gray
collie syndrome". Sable "gray collie syndrome" dogs have brown or pale
sable noses, but never black noses as they should have.
DNA TEST
HealthGene Laboratory is the first DNA diagnostic laboratory that has
developed and offered a DNA-based test for Canine Cyclic Neutropenia.
HealthGene's test provides a reliable identification of dogs that carry mutant
gene(s). This test allows a breeder to control the mutant gene frequency in
the Collie breed thus preventing the production of puppies affected with
Canine Cyclic Neutropenia. This DNA test accurately and specifically
identifies normal, carriers (heterozygous) and affected dogs. this test has
been developed for the breeder so we can avoid this disorder
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